[nilesh]

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Can you tell me about the paper pattern and marking scheme for Graduate Pharmacy Aptitude Test (GPAT) conducted by All India Council for Technical Education (AICTE)?

[Vishal Kotkar]

GPAT - Graduate Pharmacy Aptitude Test is an online National Level Entrance Test being conducted by All India Council of Technical Education, AICTE. It offers admissions to nearly 25,000 seats. Through it, one can get admission in the post graduate course in Pharmacy, the M. Pharma course.

GPAT Exam Pattern
• Exam Mode – Online
• Exam Duration – 3 hours (2.30 PM to 5.30 PM)
• Total Questions – 125
• Maximum Marks – 500
• Type of Questions – Multiple Choice Questions (MCQs)

GPAT Marking Scheme
• Marks per question – Each question will carry 4 marks
• Negative marking – One mark will be deducted from the total score for every wrong response.
The questions marked with wrong answer option/response or marked with more than one option will be considered for negative marking.

GPAT Syllabus
Physical Chemistry: Composition and physical states of matter, Colligative properties, Thermodynamics, Chemical equilibria, Phase rule, Refractive index, Solutions, Electrochemistry, Ionic equilibrium, Kinetics.
Organic Chemistry: General principles, Different classes of compounds, Protection and deprotection of groups, Aromaticity and aromatic chemistry, Different aromatic classes of compounds, Polycyclic aromatic hydrocarbons, Carbonyl chemistry, Heterocyclic chemistry, Bridged rings, Kinetic and thermodynamic control, Stereo chemistry, Carbohydrates, Amino acids and proteins, Organometalic chemistry, Pericyclic reactions
Physical Pharmacy: Matter, properties of matter, Micrometrics and powder rheology, Surface and interfacial phenomenon, Viscosity and rheology, Dispersion systems, Complexation, Buffer, Solubility
Pharmaceutical Chemistry: Pharmaceutical impurities, Monographs, Isotopes, Therapeutic classes of drugs, Drug metabolism, Various classes of therapeutic agents, Different classes of therapeutic drugs
Pharmaceutics: Pharmacy profession, Introduction to pharmaceuticals, Introduction to dosage form, Route of administration, ADME, Sources of drug information, Allopathic dosage form, Crude extract, Allergenic extract Ayurvedic system of medicine, Homeopathic system of medicine, Biological products, GMP, Pharmaceutical plant, location, layout Dosage form necessities and additives, Powders, Capsules, Tablets Parenterals – products requiring sterile packaging, Suspensions Emulsions, Suppositories, Semisolids, Liquids, Pharmaceutical aerosols Ophthalmic preparations, Preformulations , Radio pharmaceuticals Stability of formulated products, Kinetic principles and stability testing Prolonged action pharmaceuticals, Novel drug delivery system, Cosmetics, Packaging material, GMP and validation, Pilot plant scale up techniques
Pharmacology: General pharmacology, Pharmacology for peripheral nervous system, Pharmacology of cardiovascular system, Drugs acting on urinary system, Drugs acting on respiratory system, Pharmacology of central nervous system, Pharmacology of endocrine system, Chemotherapy, Autacoids and their antagonists, Pharmacology of drugs acting on gastrointestinal tract, Chronopharmacology, Immnopharmacology, Chemotherapy of malignant diseases, Peptides and proteins as mediators, Nitric oxide, Vitamins and minerals, Principles of toxicology
Pharmacognosy: Introductory Pharmacognosy, Classification of crude drugs, Sources of crude drugs, Factors influencing quality of crude drugs, Techniques in microscopy, Introduction to phytoconstituents, Principles of plant classification, Pharmaceutical aids, Animal products, Plant products, Toxic drugs, Enzymes, Natural pesticides and insecticides, Adulteration and evaluation of crude drugs, Quantitative microscopy, Biogenetic pathways, Carbohydrates and lipids, Tannins, Volatile oils, Resinous drugs, Glycocides, Alkaloids, Herbarium, Extraction and isolation techniques, Phytopharmaceuticals, Quality control and standardization of herbal drugs, Herbal formulations, Worldwide trade of crude drugs and volatile drug, Plant biotechnology, Herbal cosmetics, Traditional herbal drugs, Plant based industries and research institutes in India Patents
Pharmaceutical Analysis: Importance of quality control in pharmacy, Acid-base titrations, Non-aqueous titrations, Oxidation-reduction titrations, Precipitation titrations, Complexometric titrations, Gravimetry, Extraction techniques , Potentiometry, Miscellaneous methods of analysis, Calibration General principles of spectroscopy, Ultraviolet-visible spectrometry Spectrofluorimetric, Flame photometry and atomic absorption spectrometry, Infrared spectrometry, Proton nuclear magnetic resonance spectrometry, Mass spectrometry, Polarography, Nephelometry and turbidimetry, Chromatography
Biochemistry : Cell, Carbohydrates, Proteins, Lipids, Vitamins, Biological oxidations and reductions, Enzymes, Nucleic Acids, Hereditary diseases
Biotechnology: Plant cell and tissue culture, Animal cell structure, Fermentation technology and industrial microbiology, Recombinant DNA Technology, Process and applications, Biotechnology derived products, Proteomics, Formulation of proteins and peptides
Microbiology: Introduction to microbiology, Microscopy and staining technique, Biology of microorganisms, Fungi and viruses, Asceptic technique, Sterilization and disinfection, Microbial spoilage, Immunology and health, Vaccines and sera, Microbial assay
Pathophysiology: Basic principles of cell injury and adaptation, Basic mechanism of inflammation and repair, Hypersensitivity, Auto immunity and diseases of immunity, Neoplastic diseases, Shock, Biological effects of radiation, Protein calorie malnutrition, vitamins, Obesity and starvation, Pathophysiology of common diseases, Infectious diseases
Biopharmaceutics and Pharmacokinetics: Bio-pharmaceutics, Bio-availability and bio-equivalence, Bio-pharmaceutical statistics
Pharmaceutical Management: Introduction to management, Planning and forecasting, Organization, Research management, Inventory management, Communication, Marketing research, Leadership and motivation, Human resource development, GATT, WTO and TRIPS, Standard institutions and regulatory authorities
Pharmaceutical Engineering : Fluid flow, Heat transfer, Evaporation, Distillation , Drying, Size reduction and size separation, Extraction, Mixing, Crystallization, Filtration and centrifugation, Dehumidification and humidity control, Refrigeration and air conditioning, Material of constructions, Automated process control systems, Industrial hazards and safety precautions
Dispensing and Hospital Pharmacy: Introduction to laboratory equipment, weighing methodology, handling of prescriptions, labelling instructions for dispensed products. Preparations based on percolation process. Preparations based on maceration process. Study of difference between marketed and dispensed products of different dosage forms Posological calculations involved in calculation of dosage for infants. Enlarging and reducing formula, displacement value. Preparations of formulations involving allegation, alcohol dilution, isotonic solution
Pharmaceutical Jurisprudence: Historical background Drug legislation in India, Code of Ethics for Pharmacists, The Pharmacy Act 1948 (inclusive of recent amendments), Drugs and Cosmetics Act 1940, Rules 1945, including New Drug applications, Narcotic Drugs and Psychotropic Substances Act, and Rules there under, Drugs and Magic Remedies (Objectionable Advertisements) Act 1954, Medicinal and Toilet Preparations (Excise Duties) Act 1955, Rules 1976, Medical Termination of Pregnancy Act 1970 and Rules 1975, Prevention of Cruelty to Animals Act 1960, Drug (Price Control) Order, Shops and Establishment Act, Factory Act, Consumer Protection Act, Indian Pharmaceutical Industry- An Overview, Industrial Development and Regulation act 1951, Introduction to Intellectual Property Rights and Indian Patent Act 1970,An Introduction to Standard Institutions and Regulatory Authorities such as BIS, ASTM, ISO, TGA, USFDA, MHRA, ICH, WHO, Minimum Wages Act 1948, Prevention of Food Adulteration Act 1954 and Rules 1955.
Clinical pharmacy and therapeutics: General Principles, preparation, maintenance, analysis of observational records in clinical Pharmacy, Clinical trials, type and phases of clinical trials, placebo, ethical and regulatory issues including Good clinical practice in clinical trials, Therapeutic drug monitoring, adverse drug reaction (ADR), types of ADR, Mechanism of ADR. Drug interaction, Monitoring and reporting of ADR and its significance, Drug information services, Drug interactions, Drug interaction in pediatric and geriatric patients, drug treatment during pregnancy, lactation and menstruation, Pharmacovigilance, Therapeutic drug monitoring, Nutraceuticals, essential drugs and rational drug usage, Age related drug therapy: concept of posology, drug therapy for neonates, pediatrics and geriatrics. Drugs used in pregnancy and lactation, Drug therapy in gastrointestinal, hepatic, renal, cardiovascular and respiratory Disorders, Drug therapy for neurological and psychological disorders, Drug therapy in infections of respiratory system, urinary system, infective meningitis, TB, HIV, malaria and filaria. Drug therapy for thyroid and parathyroid disorders, diabetes mellitus, menstrual cycle disorders, menopause and male sexual dysfunction, Drug therapy for malignant disorders like leukemia, lymphoma and solid tumors, Drug therapy for rheumatic, eye and skin disorders.