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Hi buddy I have come to collect Graduate Pharmacy Aptitude Test (GPAT) question paper to do preparation of this exam so will you plz let me know fro where I can do download it ??

[vikash]

Graduate Pharmacy Aptitude Test (GPAT) conducted by the All India Council For Technical Education (AICTE).

As you want here I am providing Graduate Pharmacy Aptitude Test (GPAT) question paper :

Graduate Pharmacy Aptitude Test (GPAT) question paper

Q.1.Which of the following respective Phase-I and Phase-II reactions are the most common drug
biotransformation reactions?
(A) Oxidation and Glucuronidation
(B) Reduction and Acetylation
(C) Hydrolysis and Glucuronidation
(D) Oxidation and Glutathion conjugation
Ans : A
Q.2 Which one of the following drugs has positive inotropic and negative chronotropic action?
(A) Dopamine (B) Epinephrine (C) Digoxin (D) Isoprenaline
Ans: C
Q.3 Which one of the following therapeutic classes has been proved clinically as a first line therapy for
heart failure and has shown decreased hospitalization, improved symptoms and delayed disease
progression?
(A) Cardiac glycosides B) ACE Inhibitors (ACEIs) (C) Renin Antagonists (D) Nitrites
Ans: B
Q.4 Which one of the following glucose transporters is the new drug target for the management of
Type-2 diabetes mellitus?
(A) Sodium glucose linked transporter-2 (SGLT2)
(B) Glucose transporter-1 (GLUTl)
(C) Sodium glucose linked transporter-1 (SGLTl)
(D) Glucose transporter-2 (GLUT2)
ANS. A
Q.5 Which one of the following modes of HIV transmission carries highest relative risk of
infection with single exposure?
(A) Transfusion of blood and blood products
(B) Perinatal - from mother to child
(C) Sexual contacts with infected partners
(D) Syringe sharing with drug addicts
Ans. A
Q.6 Which of the followings are the critical neurotransmitters playing major role in depression?
(A) Acetylcholine, Norepinephrine and Dopamine
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(B) Dopamine, Norepinephrine and Serotonin
(C) Serotonin, Dopamine and y-Amino butyric acid
(D) Acetylcholine, Serotonin and y-Amino butyric acid
Ans. B
Q.7 A 55 years old man is under DOTS treatment for pulmonary tuberculosis for the last four
months. Now, he has developed symptoms of peripheral neuritis. Which one of the followings is the
right addition to his therapy to manage peripheral neuritis?
(A) Cyanocobalamin (B) α-Lipoic acid
(C) Pyridoxine (D) Prednisolone
ANS: C
Q.8 What is the primary mechanism of action of local anesthetics?
(A) Activation of ligand-gated potassium channels
(B) Blockade of voltage-gated sodium channels
(C) Stimulation of voltage-gated N-type calcium channels
(D) Blockade of GABA-gated chloride channels
ANS. B
Q.9 Which one of the following anti-asthmatic drugs can cause convulsions and arrhythmia?
(A) Prednisolone (B) Salmeterol (C) Zafirlukast (D) Theophylline
ANS.D
Q.10 Which one of the following anti-arrhythmic drugs acts by inhibiting potassium, sodium and
calcium channels?
(A) Quinidine (B) Lignocaine (C) Amiodarone (D) Flecainide
ANS: C
Q.11 A 48 years old woman is having the symptoms of weight gain, cold intolerance, constipation,
bradycardia, puffy face, lethargy and dry skin. These symptoms are suggestive of which of the
followings?
(A) Over use of corticosteroid (B) Hypothyroidism
(C) Estrogen deficiency (D) Over use of thyroxin sodium
ANS: B
Q.12 Increased risk of hypoglycemia and weight gain is the common side effect of drugs used in the
management of Type-2 diabetes mellitus. Followings are some commonly used drugs, alone or in

combination, for the management of Type-2 diabetes mellitus:
[P] : Metformin [Q]: Pioglitazone
[R]: Glipizide [S] : Sitagliptin
Choose the correct combination which is weight neutral and without risk of hypoglycemia.
(A) P and Q (B) Q and R (C) R and S (D) P and S
ANS: D ( MAJOR TEST - 1)
Q.13 Which one of the following receptors is NOT a ligand-gated ion channel receptor?
(A) Nicotinic Receptor (B) 5HT3 - Receptor
(C) GABAA - Receptor (D) H2 – Receptor
ANS: D
Q.14 Which one of the following classes of drugs causes side effects like dryness of mouth,
tachycardia, urinary retention, constipation, blurring of vision, precipitation of glaucoma, drowsiness
and impairment of cognition?
(A) Anti-adrenergic (B) Anti-cholinergic
(C) An ti-serotonergic (D) Anti-dopaminergic
ANS: B
Q.15 Which of the following cytokines are the most important regulators in inflammation and are the
targets for anti-inflammatory agents used in rheumatoid arthritis?
(A) Tumor necrosis factor-a and Interleukin-1
(B) Acetylcholine esterase and Eicosanoids
(C) Leukotrienes and Isoprostanes
(D) Adhesion factor and Monoamine oxidase A
ANS: A (MINOR TEST-3 )
Q.16 Which one of the followings is a FALSE statement for competitive antagonists?
(A) They have an affinity for the agonist binding site on receptor
(B) They have no intrinsic activity
(C) They cause parallel rightward shift of the control dose response curve
(D) Maximum response of the agonist cannot be achieved in their presence by increasing the
concentration of the agonist.
ANS: D ( MINOR TEST -1 )
Q.17 Atypical antipsychotics differ from the typical antipsychotics in various ways that define them
as atypical. Which one of the followings is NOT a defining property of the atypical antipsychotics?
(A) Sustained hyperprolactinemia
(B) Improved efficacy in treating the negative symptoms

(C) Lower risk for extrapyramidal side effects (EPSs)
(D) Greater serotonin receptor blockade than dopamine blockade
ANS: A
Q. 18 Which one of the following drugs produces significant relaxation of both venules and arterioles?
(A) Hydralazine (B) Minoxidil
(C) Diazoxide (D) Sodium nitroprusside
ANS: D ( MINOR TEST- 6)
Q.19 Antiviral action of purine analogues is primarily related to the followings:
[P] : Inhibition of RNA synthesis [Q] : Inhibition of DNA polymerase
[R] : Immunomodulation [S] : Inhibition of viral penetration
Choose the correct option:
(A) R is correct and Q is incorrect (B) Q is correct and S is incorrect
(C) P is correct and R is incorrect (D) S is correct and P is incorrect
ANS: B
Q.20 All of the given four drugs are sympathomimetics:
[P] : Adrenaline [Q]: Isoprenaline
[R] : Phenylephrine [S] : Noradrenaline
Choose the correct statement related to their effects on blood pressure.
(A) P and Q increase systolic and diastolic blood pressure
(B) Q and R increase systolic and diastolic blood pressure
(C) R and S increase systolic blood pressure
(D) P and S increase systolic and diastolic blood pressure
ANS: C

Exam Pattern

Exam Mode: The examination will be carried out as online Computer Based Test (CBT) where questions will be shown on a computer screen.

Type of Questions: The question paper will contain multiple-choice questions only.

Maximum Marks: There will be total 125 questions carrying 500 marks.

Medium: The medium of the test paper will be English only.

Exam Duration: The duration of the examination will be 3 hours.

Marking Scheme: Each right answer will carry 4 marks.

Negative Marking: The wrong answer will result in negative marking. For each wrong answer, 1 mark will be deducted. Question not attempted will result in zero marks.