[Kavita]

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I shifted to Thousand Oaks, CA and came to know about the Amgen Bite Technology which is related to Cancer Cells. Will you please provide me basic details about Cancer Cells Amgen Bite Technology and also provide complete address and contact details of Amgen Inc. Corporation?

[Vishal Kotkar]

BiTE® Antibodies: Designed to Bridge T Cells to Cancer Cells
An Investigational Technology from Amgen

Cytotoxic T-Lymphocytes (CTLs) have an innate ability to target tumor cells, and evidence supports a role for immunosurveillance in tumor targeting.

By recognizing and binding to tumor cells, CTLs can lead to tumor cell lysis.

Tumor cells can evade destruction by cytotoxic T cells
Modification of tumor microenvironment by secretion of immunosuppressive cytokines such as TGF-β2
Modification of immune cell repertoire by stimulation of immunosuppressive response2,3
Generation of IDO2
Loss or mutation of MHC class I on tumor cells2
Interference with perforin/granzyme pathway4,5
Exploitation of immune-checkpoint proteins
Increased CTLA-4 expression on T cells counteracts CD284
Increased PD-1 expression on T cells4
Inhibition of kinases involved in T cell activation5
Persistent PD-1 expression causing T cell exhaustive state5
Increased PD-L1 expression on tumor cell surface4

Contact:

Corporate Headquarters
Amgen Inc.
One Amgen Center Drive
Thousand Oaks, CA 91320-1799
Phone: +1 805-447-1000
Fax: +1 805-447-1010