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Sathyabama Institute of Science and Technology M.Tech - Medical Instrumentation SBMA5102 Biosensing Technologies Syllabus

SATHYABAMA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL OF BIO AND CHEMICAL ENGINEERING

SBMA5102 BIOSENSING TECHNOLOGIES
L T P Credits Total Marks
3 0 0 3 100

UNIT 1 INTRODUCTION 9 Hrs.
General Configuration and functional description of measuring instruments-Characteristics of instrument - Static
characteristics - Dynamic characteristic, Error in the measurements. Overview of Biosensors, Fundamental elements of
biosensor devices, advantages and limitations, components of biological elements and their immobilization techniques.

UNIT 2 PHYSICAL & CHEMICAL SENSORS 9 Hrs.
Sensors for physical measurands: pressure, acceleration, flow, volume, temperature and biopotentials. Sensors for
measurement of chemicals, ion selective electrodes, ISFETS; Amperometric sensors, Clark Electrode; Biosensors, Catalytic
biosensors, Immunosensors. Smart sensors: Introduction -Primary sensors, Converters, Compensation, Recent trends in
sensor technology, Semi conductor IC technology

UNIT 3 TRANSDUCERS 9 Hrs.
Classification of transducers-Resistive, Capacitive, Inductive, Potentiometers, Temperature Compensation, Resistance
Hygrometer, Linear variable differential transformer, Capacitive displacement transducers, Equibar differential pressure
transducer , Photoelectric, piezoelectric and mechanoelectronics, Principle of fiber optic cable, fiberoptic sensors, Photo
acoustic sensors.

UNIT 4 ELECTRODES & AMPLIFIERS 9 Hrs.
Half cell potential, Reference electrodes, polarization effects, Polarisable and nonpolarisable electrodes, Micro electrodes,
Equivalent Circuits, Liquid and solid ion exchange membrane electrode, Enzyme electrode Signal Conditioning circuits-
Characteristics of Amplifiers, Differential Amplifiers, Filters, A/D Converters.

UNIT 5 NON ELECTRICAL PARAMETER MEASUREMENTS 9 Hrs.
Measurements of Respiration Rate, Temperature, Pulse rate, Blood pressure Measurements - Direct, Indirect, Blood flow
Measurements–Invitro, Invivo, Gas flow measurements.
Max. 45 Hrs.

TEXT / REFERENCE BOOKS
1. Richard S.C.Cobbold: Transducers for Biomedical Measurements: Principles and Applications, John Wiley & Sons,
1992.
2. A.P.F.Turner, I.Karube & G.S.Wilson: Biosensors: Fundamentals & Applications, Oxford University Press, Oxford,
1987.
3. Rangan C.S., Sarma G.R., and Mani V.S.V., Instrumentation devices and system, Second Edition, Tata McGraw Hill
Publishing Company Limited, New Delhi, 2006.
4. John G. Webster, Medical Instrumentation, Application and Design, 3rd Edition, John Willey and Sons, 1999.
5. Jacob Kline, Handbook of Bio Medical Engineering, Academic press Inc., Sandiego, 1988.

END SEMESTER EXAMINATION QUESTION PAPER PATTERN
Max. Marks: 100 Exam Duration: 3 Hrs.
PART A: 5 Questions of 6 marks each - No choice 30 Marks
PART B: 2 Questions from each unit with internal choice, each carrying 14 marks 70 Marks